PT-141 10mg

Description

PT‑141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from the α‑MSH sequence. It activates MC1R and MC4R, enhancing sexual arousal by modulating neuroendocrine pathways in the central nervous system. Widely used in preclinical models to study sexual function and melanocortin receptor signaling.

Sequence & Chemical Properties

• Sequence: Ac‑Arg‑Lys‑Lys‑Arg‑Ala‑His‑D‑Phe‑Arg‑Trp‑Lys‑Pro‑Lys‑Notr‑Ala‑Gly‑​ (cyclic via lactam bridge)
• Molecular Formula: C₅₅H₇₀N₁₆O₁₀
• Molecular Weight: 1,207.27 Da
• CAS Number: 189691-06-3

Research & Applications

• Sexual Arousal Models: Demonstrates dose‑dependent increases in genital blood flow and sexual behavior in rodent and primate models.1
• Melanocortin Pathway Studies: Used to elucidate the role of MC4R in libido regulation and energy homeostasis.2
• Non‑PEP Therapeutic Development: Serves as a lead compound for developing non‑hormonal sexual dysfunction therapies.

Recommended Usage

• In Vitro: 100 nM – 1 µM in receptor binding or signaling assays.
• In Vivo (Rodent): Typical dosing ranges from 0.5 – 2 mg/kg via subcutaneous or intraperitoneal injection, per protocol.1
• Solubility: Soluble in sterile water; dilute to working concentration immediately before use.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.
• Shelf Life: Up to 12 months unopened.
• Storage Conditions: Store at −20 °C; protect from moisture and light; avoid repeated freeze–thaw cycles.

All products are sold strictly for laboratory and analytical research use only. Not for human or veterinary consumption.

References

1. Weinstock, J. et al. “Bremelanotide (PT‑141) increases genital blood flow in female rats.” J Sex Med. 2006;3(1):65–73. https://pubmed.ncbi.nlm.nih.gov/16423215/
2. Dhillo, W. S. et al. “Role of Melanocortin Receptors in Sexual Behavior.” Endocrinology. 2005;146(1):185–191. https://academic.oup.com/endo/article/146/1/185/2979690