Nonapeptide-1 10mg

Description

Nonapeptide-1 is a synthetic, biomimetic peptide used in cosmetic and preclinical research to reduce hyperpigmentation and even skin tone. It acts primarily as an antagonist of α-melanocyte-stimulating hormone (α-MSH) signaling in melanocytes and has been shown in laboratory studies to lower melanin synthesis by down-regulating key melanogenic pathways (MC1R, MITF, tyrosinase and related enzymes). Nonapeptide-1 is commonly investigated for topical brightening formulations and ex-vivo skin models where controlled reduction of melanin production is desired.

Key Benefits (research context)

• Inhibits α-MSH–mediated cAMP signaling in melanocytes.

• Reduces tyrosinase activity and expression of melanogenesis markers (MITF, TRP-1/2) in cell assays.

• Supports formulation development for skin-brightening topical products and spot-correction studies.

• Typically well tolerated in formulation studies when used at appropriate concentrations.

Sequence & Chemical Data

• Amino Acid Sequence: H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂

• CAS Number: 158563-45-2

• Molecular Weight: ~1,206.5 Da

• Appearance: White to off-white lyophilized powder

Research & Applications

• Topical/ex-vivo studies investigating reduction of UV-induced and post-inflammatory hyperpigmentation.

• In vitro melanocyte assays measuring melanin content, tyrosinase activity, and melanosome transfer.

• Formulation R&D for serums and ampoules designed to even skin tone and correct localized pigmentation.

Recommended Usage (research)

• In Vitro (cell culture): 0.1 – 10 µM (titrate to assay and cell line).

• Topical / Ex-Vivo Formulations (exploratory): 0.005% – 0.05% w/v as a starting range; optimize stability, pH, and vehicle for each formulation.

• Dissolution: Soluble in sterile water or aqueous buffers; gentle vortexing and brief warming (~30–37 °C) may aid dissolution.

• Compatibility: Compatible with typical cosmetic aqueous carriers; test for interactions with oxidizers and strong acids/bases.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.

• Shelf Life: Up to 12 months unopened (validate with COA).

• Storage: Store at −20 °C for long term or 2–8 °C short term; protect from light and moisture; avoid repeated freeze–thaw cycles.

For laboratory and cosmetic research use only. Not for human or veterinary consumption.
Do not make clinical or medical claims on labeling or marketing — use data-backed, research-grade language only. Perform formulation and safety testing (cytotoxicity, irritation) before any topical application studies.