KPV 10mg

Description

KPV is a bioactive tripeptide fragment derived from the C-terminal sequence of alpha–melanocyte–stimulating hormone (α-MSH). It demonstrates potent anti-inflammatory and immunomodulatory effects by binding to melanocortin receptors and reducing pro-inflammatory cytokine release in various cell models.

Sequence

• Amino Acid Sequence: Lys–Pro–Val
• Other Names: α-MSH (11–13); Lys-Pro-Val Peptide

Research & Applications

• Anti-Inflammatory Activity: Reduces TNF-α, IL-1β, and IL-6 secretion in LPS-stimulated macrophages, supporting studies in inflammatory bowel disease and skin inflammation.
• Wound Healing: Promotes keratinocyte migration and accelerates wound closure in vitro, making it a tool for epithelial repair assays.
• Immune Modulation: Modulates dendritic cell maturation and T-cell activation, useful in autoimmune and transplant research.

Recommended Usage

• In Vitro: 1 – 50 µM in culture media for inflammation assays.
• Solubility: Soluble in sterile water or PBS; gentle warming (~37 °C) may aid dissolution.
• Compatibility: Compatible with serum-free and low-serum formulations.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.
• Shelf Life: Up to 12 months unopened.
• Storage Conditions: Store at −20 °C; protect from moisture and light; avoid repeated freeze–thaw cycles.

All products are sold strictly for laboratory and analytical research use only. Not for human or veterinary consumption.

References

• MedChemExpress. KPV Tripeptide (Catalog No. HY-P0208), 10 mg. https://www.medchemexpress.com/hy-p0208.html
• Peptide Sciences. KPV (10 mg). https://www.peptidesciences.com/products/lyz-pro-val-kpv-tripeptide
• Cui, X. et al. “KPV peptide attenuates inflammatory responses in LPS-stimulated RAW264.7 macrophages.” Inflammation Research. 2019;68:863–872. https://pubmed.ncbi.nlm.nih.gov/31460471/
• Brzoska, T. et al. “KPV accelerates wound healing in human HaCaT keratinocytes.” Journal of Peptide Science. 2013;19(4):255–261. https://pubmed.ncbi.nlm.nih.gov/23652735/