Dihexa 10mg

Description

Dihexa is a small, blood-brain-barrier-permeable oligopeptide derived from angiotensin IV and developed as a potent synaptogenic/neurotrophic agent. In preclinical studies it potentiates hepatocyte growth factor (HGF) activity at the c-Met receptor and promotes spinogenesis and synaptogenesis, producing robust pro-cognitive effects in rodent models of cognitive impairment. PubMedWikipedia

Sequence & Chemical Data

• Chemical name (representative): N-hexanoic-Tyr-Ile-(6)-aminohexanamide (commonly referenced as “Dihexa”)

• Molecular Formula: C₂₇H₄₄N₄O₅

• Molecular Weight: ~504.66 Da

• CAS / Identifiers: CAS 1401708-83-5; PubChem CID 129010512

Mechanism (summary)

Dihexa binds with high affinity to hepatocyte growth factor (HGF) and potentiates HGF–c-Met signaling, a pathway implicated in synaptic growth and neuronal repair. Through this modulation Dihexa has been shown to induce rapid formation of new dendritic spines and functional synapses in hippocampal preparations.

Research & Applications

• Cognitive enhancement / synaptogenesis: Demonstrated to improve cognition and increase synapse number in multiple rodent models of cognitive dysfunction.

• Neuroregeneration models: Used to probe mechanisms of HGF/c-Met mediated neuronal repair and plasticity.

• Translational research: Investigated as an orally active, BBB-permeable lead for neurorestorative strategies; however, long-term safety and tumorigenic risk remain incompletely characterized and require rigorous evaluation.

Note: Dihexa is a research reagent. Do not infer clinical safety or efficacy from preclinical results.

Recommended Usage (research context only)

• In Vitro: start at 0.1–1000 nM (0.0001–1 µM) for receptor/signaling and synaptogenesis assays; titrate to system sensitivity.

• In Vivo (rodent studies): published preclinical reports use a range of routes and doses — follow the primary literature and institutional animal protocols when selecting dose and route; do not extrapolate to humans.

• Solubility: Reconstitute lyophilized Dihexa in sterile water or appropriate buffer; avoid repeated freeze–thaw cycles and prepare working dilutions fresh.

• Formulation: Validate vehicle compatibility for oral, systemic, or topical delivery as required by your model.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.

• Shelf Life: Up to 12 months unopened (confirm with COA).

• Storage Conditions: Store at −20 °C for long-term storage; short-term 2–8 °C acceptable. Protect from moisture and light; avoid repeated freeze–thaw cycles.

For laboratory research use only. Not for human or veterinary consumption.
Because Dihexa modulates HGF/c-Met (a pathway with known links to oncogenesis in some contexts), labs should perform appropriate safety assessments, include proper controls, and follow institutional biosafety and animal-use policies.