Decapeptide-12 10mg

Description

Decapeptide-12 is a fully synthetic peptide composed of ten amino acids, engineered to target and inhibit tyrosinase—the key enzyme catalyzing the early steps of melanin synthesis in melanocytes. By reducing tyrosinase activity, Decapeptide-12 helps diminish hyperpigmentation, melasma, and age spots, making it a valuable tool in dermatological and cosmetic research settings.

Chemical Makeup

• Molecular Formula: C₆₅H₉₀N₁₈O₁₇

• Molecular Weight: 1,311.46 g/mol

Mechanism of Action

Decapeptide-12 exerts its skin-brightening effects primarily by:

1. Tyrosinase Inhibition: Binds to the active site of tyrosinase, reducing conversion of tyrosine → DOPA → DOPAquinone, thereby lowering eumelanin and pheomelanin production.

2. Gene Expression Modulation: Emerging evidence suggests it may downregulate TYR mRNA levels in melanocytes, further suppressing enzyme synthesis.

3. Antioxidant Support: May indirectly reduce oxidative stress in skin cells, mitigating pigmentation driven by UV-induced reactive oxygen species Reverse Peptides

Research & Clinical Studies

• Melasma Reduction: A 16-week open-label trial in 33 subjects with moderate melasma showed significant fading of hyperpigmented lesions when formulated at 0.01% Decapeptide-12 in cream base.

• Solar Lentigo Clearance: In a 24-week study, ~38.5% of participants achieved near-complete clearance of chronic sun-spot pigmentation, with all subjects exhibiting measurable improvement .

• Post-Inflammatory Hyperpigmentation: Case reports indicate accelerated resolution of inflammation-induced discoloration in Fitzpatrick IV skin types within 8 weeks of topical application

Recommended Usage

• Typical Concentration: 0.005% – 0.05% (w/v) in topical formulations (serums, lotions).

• Solubility: Readily soluble in deionized water; gentle warming (~30 °C) may improve dissolution.

• Formulation Tips: Incorporate into pH 4.5 – 6.5 vehicles; avoid strong oxidizers or proteases.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.

• Shelf Life: Up to 12 months unopened.

• Storage: Store at 2 – 8 °C; protect from light and moisture; avoid repeated freeze–thaw cycles.

All products are sold for laboratory or analytical research use only. Not for human or veterinary consumption.

References

• Core Peptides. “Decapeptide-12 (200 mg).”.

• Jiang L. et al. “Efficacy of Trifecting® Night Cream, a novel triple-acting skin brightening product.” J Clin Aesthet Dermatol. 2018;11(12):21–25..