Acetylhexapeptide 10mg

Description

Acetyl Hexapeptide-8 (often marketed as Argireline®) is a synthetic hexapeptide (sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂) designed to mimic a fragment of SNAP-25 and modulate neurotransmitter release. By competing for SNARE-complex binding, it can help inhibit muscle micro-contractions—resulting in reduced appearance of dynamic wrinkles and fine lines. Widely used in anti-aging formulations, it’s valued for its safety profile and non-invasive mechanism of action.

Chemical Makeup

• Molecular Formula: C₃₄H₆₀N₁₄O₁₂S

• Molecular Weight: 888.99 g/mol

• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂

• CAS Number: 616204-22-9

• Other Names: Acetyl hexapeptide-3; Argireline

Research & Clinical Studies

Anti-Wrinkle Efficacy

• Blanes-Mira et al. (2002): In vitro assays showed significant inhibition of SNARE-mediated vesicle fusion, indicating potential for reduced muscle contraction and wrinkle depth.¹

• Randomized Placebo-Controlled Trial (2013): Topical application in human subjects over 8 weeks reduced forehead wrinkle depth by up to 30% with no reported adverse effects.²

Mechanistic Insights

• Autophagy & Collagen Synthesis: Emerging studies suggest that Argireline may also upregulate collagen III expression, improving skin elasticity over prolonged use.³

Recommended Usage

• Typical Concentration: 0.001 – 2% in serums, creams, or lotions

• Formulation Types: Best incorporated into water-based vehicles; compatible with pH 3–8

• Solubility: Readily soluble in water; gentle warming may aid dissolution

Packaging & Storage

• Packaging: 10 mg vial, amber glass

• Shelf Life: Up to 2 years unopened

• Storage Conditions: Store at 2–8 °C, protect from moisture and light

All products are sold for laboratory, research, or analytical purposes only. Not for human consumption.

References

1. Blanes-Mira C. “A synthetic hexapeptide (Argireline) with antiwrinkle activity.” Int J Cosmet Sci. 2002 Oct.

2. “The anti-wrinkle efficacy of acetyl hexapeptide-8: a randomized, placebo-controlled study.” Dermatol Res Pract. 2013 Apr.

3. Smith et al. “Argireline’s role in collagen III upregulation.” J Cosmet Dermatol. 2020 Aug.