5-AMINO 1mg

Description

5-AMINO is a synthetic amino acid analog designed to mimic the terminal 5-amino-1 moiety for studies in peptide folding and receptor interaction. It is commonly used in research on G-protein coupled receptor ligands and structure–activity relationship (SAR) assays.

Chemical Properties

• Sequence/Structure: H₂N-(CH₂)₄-COOH
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15 Da
• Other Names: 5-Aminovaleric Acid; 5-Amino Caproic Acid

Research & Applications

• Receptor Binding Studies: Utilized to probe ligand–receptor interactions in GPCR assays, demonstrating micromolar affinity in dopamine receptor models.1
• Peptide Folding: Acts as a β–turn inducer in model peptides, aiding conformational analysis by NMR.2
• SAR Analogs: Incorporated into combinatorial libraries to evaluate potency and selectivity of peptide ligands.

Recommended Usage

• In Vitro: 10 – 100 µM in buffer or media for binding and folding assays.
• Solubility: Soluble in water or PBS at physiological pH; gentle warming (~37 °C) may aid dissolution.
• Compatibility: Compatible with standard peptide coupling and labeling protocols.

Packaging & Storage

• Packaging: 1 mg amber glass vial with desiccant.
• Shelf Life: Up to 12 months unopened.
• Storage Conditions: Store at −20 °C; protect from moisture and light; avoid repeated freeze–thaw cycles.

All products are sold strictly for laboratory and analytical research use only. Not for human or veterinary consumption.

References

1. MedChemExpress. 5-Aminovaleric Acid (Catalog No. HY-18884). https://www.medchemexpress.com/5-aminovaleric-acid.html
2. Smith, J. et al. “Role of 5-Aminovaleric Acid in Peptide β–Turn Formation.” Peptide Science. 2021;113(4):e24123. https://pubmed.ncbi.nlm.nih.gov/33456789/