Description
Tirzepatide is a long-acting, synthetic dual agonist of the gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. Engineered as a 39-amino-acid peptide with a C20 fatty acid side chain for prolonged half-life, it robustly enhances glucose-dependent insulin secretion and promotes weight loss, making it a powerful research tool in metabolic and obesity studies.
Composition
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Sequence Length: 39 amino acids
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Molecular Formula: C₂₂₇H₃₅₂N₄₈O₇₀
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Molecular Weight: ~4 810 Da
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Modification: C20 diacid moiety for extended circulation
Research & Applications
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Glucose Lowering: Demonstrates potent, sustained reductions in plasma glucose and HbA1c in preclinical and clinical models.
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Weight Management: Induces significant body-weight loss via combined GIP/GLP-1 receptor activation, outperforming selective GLP-1 agonists in head-to-head studies.
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Cardiometabolic Benefits: Improves lipid profiles and reduces markers of cardiovascular risk in animal and human trials.
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Mechanistic Studies: Used to dissect incretin receptor signaling, appetite regulation, and energy homeostasis pathways.
Recommended Usage
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In Vitro: 1–100 nM in receptor-binding or signaling assays.
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In Vivo (Rodent Studies): 0.1–1 mg/kg via subcutaneous injection, dosed once weekly or per protocol.
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Reconstitution: Dissolve in sterile water or PBS; gentle swirling may aid dissolution.
Packaging & Storage
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Packaging: 10 mg amber glass vial with desiccant pack.
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Shelf Life: Up to 12 months unopened.
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Storage Conditions: –20 °C; protect from light and moisture; avoid repeated freeze–thaw cycles.
For laboratory research use only. Not for human or veterinary consumption.
References
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PubChem: Tirzepatide Acetate (CID 169544770) pubchem.ncbi.nlm.nih.gov
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Lutz & Nauck, “The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in Metabolic Control,” Diabetes, Obesity and Metabolism (2020) pubmed.ncbi.nlm.nih.gov
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Nauck & D’Alessio, “Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for type 2 diabetes,” Cardiovascular Diabetology 21:169 (2022) cardiab.biomedcentral.com
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Wikipedia: “Tirzepatide” en.wikipedia.org
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FAQ
1. What are research peptides?
Research peptides are short chains of amino acids used in scientific and medical research. They are not approved for human consumption or therapeutic use but are studied for their potential biological effects.
2. Is Reverse Peptides a trusted source for buying peptides online?
Yes. Reverse Peptides offers 99% purity, third-party tested, and USA-made peptides. Our products are backed by quality assurance and a loyal base of researchers
3. How do I store research peptides after receiving them?
Most peptides should be stored in a cool, dry place. Lyophilized powders are typically stable at room temperature but should be refrigerated for long-term storage. Always refer to the product label.
4. What payment methods do you accept?
We accept major credit/debit cards and secure online payment options. All transactions are encrypted and secure.
5. Is a prescription required to purchase peptides from Reverse Peptides?
No. Since our peptides are sold strictly for laboratory research purposes, no prescription is required. However, buyers must be qualified researchers or institutions.
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