Thymosin Alpha-1 10mg

Description

Thymosin Alpha-1 is a naturally occurring 28-amino-acid peptide fragment derived from prothymosin α, renowned for its potent immunomodulatory effects. In research, TA1 enhances both innate and adaptive immunity by promoting T-cell maturation, improving dendritic cell function, and balancing cytokine profiles. It’s widely used in studies of viral infections, cancer immunotherapy, and immune reconstitution.

Sequence & Composition

• Amino Acid Sequence:
  Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ile-Ala-Glu-Ile-Asp-Ala-Ser-Lys-Ile-Thr-Thr-Ala-Thr-Gly-Ser-Ser-Met-Ser-Arg-Glu-NH₂

• Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅

• Molecular Weight: 3 108.5 Da

Research & Applications

• Immune Restoration: Accelerates dendritic cell maturation and enhances T-helper cell responses.

• Antiviral Studies: Improves viral clearance and reduces pathology in hepatitis and CMV models.

• Cancer Immunotherapy: Synergizes with checkpoint inhibitors to boost anti-tumor immunity.

• Inflammatory Disorders: Modulates cytokine expression to mitigate excessive inflammatory reactions.

Recommended Usage

• In Vitro: 0.1–10 µM in cell culture assays.

• In Vivo (Rodent Studies): 0.5–2 mg/kg via subcutaneous or intraperitoneal injection, per protocol.

• Solubility: Dissolve in sterile water or PBS; gentle warming (~37 °C) may aid dissolution.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant pack.

• Shelf Life: Up to 12 months unopened.

• Storage Conditions: Store at 2–8 °C; protect from light and moisture; avoid repeated freeze–thaw cycles.

For laboratory research use only. Not for human or veterinary consumption.

References

1. Wikipedia: “Thymosin Alpha-1”

2. Goldstein et al., “Isolation and sequence analysis of thymosin alpha-1,” Proc. Natl. Acad. Sci. (1977)

3. Peptide Sciences: “Thymosin Alpha-1 10 mg | 99% Purity”