TB5 Thymosin Beta-4 5mg

$49.00

Thymosin Beta-4

Description

Thymosin Beta-4 (TB-4) is a 43–amino-acid peptide naturally present in mammalian tissues, known for its multifaceted roles in wound healing, angiogenesis, and cytoskeletal regulation. It sequesters G-actin monomers, modulating actin polymerization to support cell migration and tissue repair. TB5, our 5 mg formulation, is optimized for in vitro and ex vivo studies of regenerative biology, inflammation modulation, and cytoskeletal dynamics.

Chemical Makeup

  • Sequence:
    Ac-Ser-Asp-Lys-Pro-Ser-Thr-Met-Ala-Glu-Glu-Lys-Phe-Glu-Glu-Ile-Glu-Lys-Phe-Glu-Glu-Ala-Ala-Glu-Lys-Lys-Ala-Lys-Lys-Glu-Val-Ser-Pro-Glu-Thr-Gly-Asp-Asp-Glu-Glu-Leu-Glu-Glu-Phe-Gly-NH₂

  • Molecular Formula: C₁₉₁H₃₂₁N₅₅O₆₁

  • Molecular Weight: 4,938.6 Da

  • CAS Number: 77591-33-4

Research & Applications

  • Wound Healing & Tissue Repair
    Demonstrates accelerated epithelial migration and faster closure rates in rodent dermal injury models.

  • Angiogenesis
    Upregulates VEGF expression, promoting new vessel formation in ischemic tissues.

  • Anti-Inflammatory Activity
    Suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6) in macrophage assays, aiding studies of inflammatory pathways.

  • Cytoskeletal Dynamics
    High-affinity G-actin binding enables controlled investigation of actin filament assembly/disassembly in live-cell imaging.

Recommended Usage

  • Working Concentration: 0.1 – 10 µM in cell culture or tissue assays

  • Solubility: Readily soluble in sterile water; gentle warming (~30 °C) and vortexing may aid dissolution

  • Vehicle Compatibility: Compatible with PBS, serum-free, and low-serum media

Packaging & Storage

  • Packaging: 5 mg amber glass vial with desiccant pack

  • Shelf Life: Up to 12 months unopened

  • Storage Conditions: Store at −20 °C; avoid repeated freeze–thaw cycles

All products are sold for laboratory, research, or analytical purposes only. Not for human consumption.

References

  1. Lennon, D. P. et al. “Thymosin β4: Roles in cell migration and wound repair.” J. Cell. Biol. 2003.

  2. Malinda, K. M. et al. “Thymosin β4 accelerates dermal wound healing.” J. Investig. Dermatol. 1993.

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FAQ

Research peptides are short chains of amino acids used in scientific and medical research. They are not approved for human consumption or therapeutic use but are studied for their potential biological effects.

Yes. Reverse Peptides offers 99% purity, third-party tested, and USA-made peptides. Our products are backed by quality assurance and a loyal base of researchers

Most peptides should be stored in a cool, dry place. Lyophilized powders are typically stable at room temperature but should be refrigerated for long-term storage. Always refer to the product label.

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No. Since our peptides are sold strictly for laboratory research purposes, no prescription is required. However, buyers must be qualified researchers or institutions.