Thymosin Alpha-1 2mg

Description

Thymosin Alpha-1 is a 28-amino-acid peptide fragment derived from the precursor prothymosin α, renowned for its potent immunomodulatory activity. It enhances T-cell differentiation and dendritic cell maturation, supporting both innate and adaptive immune responses. Widely used in research on infectious diseases, cancer immunotherapy, and immune regeneration, TA1 has been shown to restore immune competence in models of thymic deficiency and chronic viral infection.

Sequence & Composition

• Amino Acid Sequence:
  Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ile-Ala-Glu-Ile-Asp-Ala-Ser-Lys-Ile-Thr-Thr-Ala-Thr-Gly-Ser-Ser-Met-Ser-Arg-Glu-NH₂

• Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅

• Molecular Weight: 3,108.5 Da

Research & Applications

• Immune Restoration: Promotes maturation and antigen-presenting function of dendritic cells, enhancing T-helper and cytotoxic T-lymphocyte activation.

• Antiviral Studies: Improves viral clearance and reduces pathology in models of chronic hepatitis and cytomegalovirus infection.

• Cancer Immunotherapy: Augments checkpoint-inhibitor efficacy and supports immune reconstitution post-chemotherapy in preclinical tumor models.

• Inflammatory Disorders: Modulates cytokine profiles, reducing excessive inflammatory responses in sepsis and acute respiratory distress syndrome (ARDS) models.

Recommended Usage

• In Vitro: 0.1–10 μM in cell culture assays.

• In Vivo (Rodent Studies): 0.5–2 mg/kg via subcutaneous or intraperitoneal injection, daily or per protocol.

• Solubility: Dissolve in sterile water or PBS; gentle warming (~37 °C) may aid dissolution.

Packaging & Storage

• Packaging: 2 mg amber glass vial with desiccant pack.

• Shelf Life: Up to 12 months unopened.

• Storage Conditions: Store at 2–8 °C; protect from moisture and light; avoid repeated freeze–thaw cycles.

For laboratory research use only. Not for human or veterinary consumption.

References

1. Wikipedia: “Thymosin α1” en.wikipedia.org

2. Goldstein et al., “Isolation and sequence analysis of thymosin alpha-1,” Proc. Natl. Acad. Sci. (1977) pnas.org

3. Peptide Sciences: “Thymosin Alpha-1 10mg | 99% Purity” peptidesciences.com