MOTS-c 10mg

Description

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA. It translocates to the nucleus under metabolic stress and regulates adaptive gene expression via AMPK activation. In research settings, MOTS-c is studied for its roles in enhancing skeletal muscle glucose uptake, improving insulin sensitivity, promoting mitochondrial–nuclear communication, and supporting longevity and exercise-mimetic pathways¹.

Sequence & Composition

• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

• Molecular Weight: 2 174.6 Da²

• Appearance: White to off-white lyophilized powder³

Research & Applications

• Metabolic Regulation: Activates AMPK in muscle cells, increasing GLUT4 expression and glucose uptake independent of insulin².

• Exercise Mimetic: Upregulated by physical exercise; improves endurance and reduces fat accumulation in animal models¹.

• Stress Response & Longevity: Translocates to the nucleus under nutrient stress to modulate antioxidant and heat-shock response genes⁴.

• Clinical Implications: Investigated for potential benefits in obesity, type 2 diabetes, and age-related metabolic decline¹.

Recommended Usage

• In Vitro: 0.1–10 µM in cell culture assays (dissolve in sterile water or PBS; gentle warming may aid solubility).

• In Vivo (Rodent Studies): 0.5–2 mg/kg via intraperitoneal or intravenous injection, once daily or per protocol.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant pack.

• Shelf Life: Up to 12 months unopened.

• Storage Conditions: Store at 2–8 °C; protect from light and moisture; avoid repeated freeze–thaw cycles.

For laboratory research use only. Not for human or veterinary consumption.

References

1. Wikipedia: “MOTS-c” en.wikipedia.org

2. Particle Peptides: “MOTS-c 10 mg” product overview particlepeptides.com

3. MedChemExpress: “MOTS-c (human)” product data medchemexpress.com

4. Lee C. et al., “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism,” Free Radical Biology and Medicine, 2016 pmc.ncbi.nlm.nih.gov