SKU: SQ8107716

MOTS-c 10mg

$89.00

MOTS-c 10mg

Description

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA. It translocates to the nucleus under metabolic stress and regulates adaptive gene expression via AMPK activation. In research settings, MOTS-c is studied for its roles in enhancing skeletal muscle glucose uptake, improving insulin sensitivity, promoting mitochondrial–nuclear communication, and supporting longevity and exercise-mimetic pathways¹.

Sequence & Composition

  • Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

  • Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

  • Molecular Weight: 2 174.6 Da²

  • Appearance: White to off-white lyophilized powder³

Research & Applications

  • Metabolic Regulation: Activates AMPK in muscle cells, increasing GLUT4 expression and glucose uptake independent of insulin².

  • Exercise Mimetic: Upregulated by physical exercise; improves endurance and reduces fat accumulation in animal models¹.

  • Stress Response & Longevity: Translocates to the nucleus under nutrient stress to modulate antioxidant and heat-shock response genes⁴.

  • Clinical Implications: Investigated for potential benefits in obesity, type 2 diabetes, and age-related metabolic decline¹.

Recommended Usage

  • In Vitro: 0.1–10 µM in cell culture assays (dissolve in sterile water or PBS; gentle warming may aid solubility).

  • In Vivo (Rodent Studies): 0.5–2 mg/kg via intraperitoneal or intravenous injection, once daily or per protocol.

Packaging & Storage

  • Packaging: 10 mg amber glass vial with desiccant pack.

  • Shelf Life: Up to 12 months unopened.

  • Storage Conditions: Store at 2–8 °C; protect from light and moisture; avoid repeated freeze–thaw cycles.

For laboratory research use only. Not for human or veterinary consumption.

References

  1. Wikipedia: “MOTS-c” en.wikipedia.org

  2. Particle Peptides: “MOTS-c 10 mg” product overview particlepeptides.com

  3. MedChemExpress: “MOTS-c (human)” product data medchemexpress.com

  4. Lee C. et al., “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism,” Free Radical Biology and Medicine, 2016 pmc.ncbi.nlm.nih.gov

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FAQ

Research peptides are short chains of amino acids used in scientific and medical research. They are not approved for human consumption or therapeutic use but are studied for their potential biological effects.

Yes. Reverse Peptides offers 99% purity, third-party tested, and USA-made peptides. Our products are backed by quality assurance and a loyal base of researchers

Most peptides should be stored in a cool, dry place. Lyophilized powders are typically stable at room temperature but should be refrigerated for long-term storage. Always refer to the product label.

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No. Since our peptides are sold strictly for laboratory research purposes, no prescription is required. However, buyers must be qualified researchers or institutions.