Hexarelin 2mg

Description

Hexarelin is a potent synthetic growth hormone–releasing peptide (GHRP) that mimics the action of the endogenous ligand ghrelin to activate the growth hormone secretagogue receptor (GHSR). Compared to ghrelin, Hexarelin exhibits greater chemical stability and a longer half-life, making it a preferred tool for research on GH release, cardioprotection, and metabolic regulation.

Chemical Makeup

• Sequence: His-D-2Nal-Ala-Trp-D-Phe-Lys-NH₂

• Molecular Formula: C₄₇H₅₈N₁₂O₆ UMBRELLA Labs

• Molecular Weight: 887.0 Da UMBRELLA Labs

• CAS Number: 140703-51-1 UMBRELLA Labs

• Other Names: Examorelin; EP-23905; MF-6003 UMBRELLA Labs

Research & Applications

• Growth Hormone Release
  Hexarelin stimulates a rapid and robust GH surge, peaking around 30 minutes post-administration and returning to baseline by 4 hours. It has been extensively used to characterize pituitary GH secretory dynamics in adult models PARTICLE, s. r. o.PubMed.

• Cardioprotective Effects
  In rodent ischemia-reperfusion studies, Hexarelin reduced myocardial apoptosis, preserved ventricular function, and diminished fibrotic remodeling via modulation of autophagy pathways Peptide SciencesUMBRELLA Labs.

• Metabolic Regulation
  By elevating circulating GH and downstream IGF-1, Hexarelin has been shown to promote lean mass retention and modulate lipid metabolism in animal models of cachexia PARTICLE, s. r. o..

Recommended Usage

• Working Concentration: 100 nM – 1 µM in vitro; for in vivo dosing, typical range is 100 µg – 200 µg per kg body weight (adjust per protocol) PubMed

• Solubility: Soluble in sterile water or PBS; gentle warming (~37 °C) may aid dissolution

• Vehicle Compatibility: Compatible with serum-free or low-serum buffers

Packaging & Storage

• Packaging: 2 mg amber glass vial, lyophilized

• Shelf Life: Up to 12 months unopened

• Storage Conditions: Store at 2–8 °C; do not freeze; avoid repeated freeze–thaw cycles UMBRELLA Labs

All products are sold for laboratory research use only. Not for human or veterinary consumption.

References

1. Bellone J. et al. “Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in adults.” J. Endocrinol. Invest. 1998 Sep;21(8):494–500. PubMed

2. Zhang T. et al. “Hexarelin protects heart cells from hypertrophy by stimulating autophagy.” Peptide Sci. 2020.

3. “Hexarelin vs GHRP-6: Potential in muscle and cardiac function.”