Chonluten 10mg

Description

Chonluten is a short tripeptide bioregulator of gene expression, composed of glutamic acid–aspartic acid–glycine (Glu-Asp-Gly). It exhibits its highest activity in lung tissue, where it modulates genes involved in inflammation, antioxidant defenses, and mucosal repair, with secondary effects in the gastrointestinal tract.

Sequence

• Amino Acid Sequence: Glu–Asp–Gly (EDG)
• Other Names: Tripeptide T-34; EDG Peptide

Research & Applications

• Pulmonary Inflammation: Shown to regulate expression of pro- and anti-inflammatory cytokines (e.g., TNF-α, IL-6) in bronchial epithelial models, improving mucosal barrier function in chronic inflammatory lung diseases.
• Gastrointestinal Protection: Demonstrates anti-inflammatory and antioxidant gene modulation in GI tissues, suggesting potential utility in research on Crohn’s disease and ulcerative colitis.
• Gene Expression Modulation: Acts at the transcriptional level, influencing genes such as c-Fos and HSP70 to support proliferative and repair responses in vitro.

Recommended Usage

• In Vitro: 1 – 20 µM in cell culture or assay buffer.
• Dissolution: Soluble in sterile water or phosphate-buffered saline; gentle warming (~37 °C) may aid solubility.
• Compatibility: Suitable for serum-free and low-serum formulations.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.
• Shelf Life: Up to 12 months unopened.
• Storage: Store at −20 °C; protect from moisture and light; avoid repeated freeze–thaw cycles.

All products are sold strictly for laboratory and analytical research use only. Not for human or veterinary consumption.

References

• Peptide Sciences. Chonluten 20 mg (Bioregulator). https://www.peptidesciences.com/collections/bioregulators/products/chonluten
• Khavinson V.K. et al. Peptides regulating proliferative activity and inflammatory processes in human monocytic THP-1 cells. Biogerontology. PMCID: PMC8999041. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999041/
• Oneindia English Desk. The Gene Expression Potential of Chonluten Peptide. OneIndia.com. https://www.oneindia.com/2023/11/03/the-gene-expression-potential-of-chonluten-peptide.html