AOD 9604 2mg

Description

AOD-9604 is a synthetic 16-amino-acid fragment corresponding to residues 177–191 of human growth hormone, engineered to retain GH’s lipolytic activity while minimizing effects on IGF-1. Orally active and chemically stable, it’s widely used in research on fat metabolism, obesity models, and adipocyte biology.

Composition

• Sequence: Tyr–Leu–Arg–Ile–Val–Gln–Cys–Arg–Ser–Val–Glu–Gly–Ser–Cys–Gly–Phe

• Disulfide Bridge: Cys⁷–Cys¹⁴

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

• Molecular Weight: ~1 815 Da

• CAS Number: 221231-10-3

Research & Applications

• Lipolysis Studies: Enhances fat breakdown in rodent obesity models without stimulating IGF-1, making it a tool for adipose tissue research.

• Safety & Tolerability: Demonstrated a favorable safety profile in Phase I human trials, supporting its use in mechanistic and metabolic studies.

• Metabolic Regulation: Employed to dissect GH-mediated pathways in vitro and in vivo, including β₃-adrenergic receptor–mediated lipolytic mechanisms.

Recommended Usage

• In Vitro: 1–20 µM in cell culture assays.

• In Vivo (Rodent Studies): 100–300 µg/kg via subcutaneous or intraperitoneal injection, once daily or per protocol.

• Solubility: Dissolve in sterile water or PBS; gentle warming (~37 °C) may aid dissolution.

Packaging & Storage

• Packaging: 2 mg amber glass vial with desiccant pack.

• Shelf Life: Up to 12 months unopened.

• Storage: 2–8 °C; protect from light and moisture; avoid repeated freeze–thaw cycles.

For research use only. Not for human or veterinary consumption.

References

1. Wikipedia: “AOD9604” en.wikipedia.org

2. PubChem: AOD-9604 (CID 71300630) pubchem.ncbi.nlm.nih.gov

3. DrugBank: AOD-9604 (DB06388) go.drugbank.com

4. Stier H. et al., “Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans,” Journal of Endocrinology and Metabolism, 2013 jofem.org