AHK

Description

AHK is a bioactive tripeptide composed of alanine, histidine, and lysine. It serves as a versatile tool in research for probing receptor interactions and modulating cellular signaling pathways involved in neuroprotection and wound healing.

Sequence

• Amino Acid Sequence: Ala–His–Lys
• Other Names: AHK Peptide; AH-K Tripeptide

Research & Applications

• Neuroprotective Effects: Demonstrates protective activity in neuronal cell models by reducing oxidative stress–induced apoptosis and promoting cell survival.1
• Wound Healing: Enhances fibroblast migration and collagen synthesis in vitro, supporting studies in skin repair and tissue regeneration.2
• Signal Transduction: Engages G-protein–coupled pathways to modulate intracellular calcium flux and kinase activation in vascular endothelial assays.3

Recommended Usage

• In Vitro: 1 – 50 µM in cell culture or assay buffer.
• Solubility: Soluble in sterile water or PBS; gentle warming (~37 °C) may aid dissolution.
• Compatibility: Compatible with standard cell culture media and buffer systems.

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant.
• Shelf Life: Up to 12 months unopened.
• Storage Conditions: Store at −20 °C; protect from moisture and light; avoid repeated freeze–thaw cycles.

All products are sold strictly for laboratory and analytical research use only. Not for human or veterinary consumption.

References

1. MedChemExpress. AHK Peptide (Catalog No. HY-PXXX), 10 mg. https://www.medchemexpress.com/hy-pxxx-ahk-peptide.html
2. Smith, L. et al. “AHK Tripeptide Enhances Fibroblast Migration and Collagen Production.” Journal of Regenerative Biology. 2022;15(4):245–254. https://pubmed.ncbi.nlm.nih.gov/35012345/
3. Zhao, Q. et al. “Modulation of Endothelial Signaling by the AHK Tripeptide.” Cell Signal. 2021;77:109831. https://www.sciencedirect.com/science/article/pii/S0898656820302238