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Description MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA. It translocates to the nucleus under metabolic stress and regulates adaptive gene expression via AMPK activation. In research settings, MOTS-c is studied for its roles in enhancing skeletal muscle glucose uptake, improving insulin sensitivity, promoting mitochondrial–nuclear communication, and supporting longevity and exercise-mimetic pathways¹….
Tirzepatide is a dual GIP and GLP-1 receptor agonist developed to manage type 2 diabetes and support weight loss. By mimicking two natural incretin hormones, it helps regulate blood sugar, suppress appetite, and enhance insulin sensitivity. It is widely studied for its potential in treating obesity and metabolic syndrome.
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