TA10 Thymosin Beta-4 10mg

Description

Thymosin Beta-4 (TB-4) is a naturally occurring, 43-amino-acid peptide that plays key roles in wound healing, angiogenesis, and cytoskeletal organization. It sequesters G-actin monomers, modulating actin polymerization dynamics. In research settings, TA10 is used to investigate tissue repair mechanisms, cell migration, and anti-inflammatory pathways.

Chemical Makeup

• Sequence:
  Ac-Ser-Asp-Lys-Pro-Ser-Thr-Met-Ala-Glu-Glu-Lys-Phe-Glu-Glu-Ile-Glu-Lys-Phe-Glu-Glu-Ala-Ala-Glu-Lys-Lys-Ala-Lys-Lys-Glu-Val-Ser-Pro-Glu-Thr-Gly-Asp-Asp-Glu-Glu-Leu-Glu-Glu-Phe-Gly-NH₂

• Molecular Formula: C₁₉₁H₃₂₁N₅₅O₆₁

• Molecular Weight: 4,938.6 Da

• CAS Number: 77591-33-4

Research & Applications

Wound Healing & Regeneration

• In Vivo Studies: Accelerates epithelial cell migration, reducing wound closure time in rodent skin-injury models.

• Angiogenesis: Promotes new blood vessel formation via upregulation of VEGF in ischemic tissues.

Anti-Inflammatory Effects

• Cytokine Modulation: Suppresses pro-inflammatory cytokines (TNF-α, IL-6) in macrophage culture assays.

Cytoskeletal Dynamics

• Actin Sequestration: Binds G-actin with nanomolar affinity, allowing controlled study of filament assembly/disassembly in live-cell imaging.

Recommended Usage

• Working Concentration: 0.1 – 10 µM in cell culture or ex vivo tissue assays

• Solubility: Soluble in sterile water; gentle swirling or brief warming (~30 °C) may aid dissolution

• Vehicle Compatibility: Compatible with PBS, serum-free media, and low-serum formulations

Packaging & Storage

• Packaging: 10 mg amber glass vial with desiccant

• Shelf Life: Up to 12 months unopened

• Storage Conditions: Store at −20 °C; avoid repeated freeze–thaw

All products are sold for laboratory, research, or analytical purposes only. Not for human consumption.

References

1. Lennon, D. P. et al. “Thymosin β4: Roles in cell migration and wound repair.” J. Cell. Biol. 2003.

2. Malinda, K. M. et al. “Thymosin β4 accelerates dermal wound healing.” J. Investig. Dermatol. 1993.

3. Sosne, G. “Thymosin β4 and ocular surface injury.” Exp. Eye Res. 2001.